Cvs Subrahmanyam Physical Pharmaceutics 2 Pdf -
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Focused units on Micromeritics (particle size and flow properties), rheology, and the deformation of solids.
This section discusses the flow properties of liquids, semisolids, and powders. It explains Newtonian and non-Newtonian flow, plastic flow, pseudoplastic flow, and dilatant flow, along with their application in creams, gels, and suspensions. 5. Kinetics and Drug Stability
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This is the science and technology of small particles. It is vital for understanding:
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Physical Pharmaceutics II focuses on the advanced physical properties of drugs and dosage forms. While Physical Pharmaceutics I usually covers states of matter, solubility, and interfacial phenomena, Part II dives into: Kinetics and Drug Stability Rheology (Flow properties) Micromeritics (Particle technology) Coarse Dispersions (Suspensions and Emulsions)
To excel in physical pharmaceutics examinations, students must master these fundamental mathematical relationships highlighted in the text: Key Concept / Formula Application (Viscosity = Shear Stress / Shear Rate) Determining liquid flow behavior Micromeritics (Angle of Repose) Evaluating powder flow for tablet compression Kinetics (First-order shelf-life) Predicting drug expiration dates Suspensions (Stokes' Law) Reducing sedimentation rate in liquids It explains Newtonian and non-Newtonian flow, plastic flow,
Bulk density, tapped density, porosity, carr's index, Hausner ratio, and angle of repose—all of which dictate powder flowability during manufacturing. 5. Drug Stability and Chemical Kinetics
Understanding colloids is crucial for designing modern drug delivery systems like liposomes, nanoparticles, and polymeric micelles. 2. Rheology